According to the Indian Journal of Urology, about 39% of men or Assigned Males at Birth (AMAB) are affected by Premature Ejaculation.
Premature Ejaculation (PE) is Sexual Dysfunction in men or AMAB. A person with Premature Ejaculation ejaculates way too early than average time.
PE affects the sexual satisfaction of both partners in the relationship. It may be caused due to Depression, stress, and low levels of serotonin and hormones.
Antidepressants used to relieve the symptoms of Depression and Anxiety may help in treating symptoms of ED caused by psychological causes.
So can you use antidepressants for Premature Ejaculation as well? And what is the relation between antidepressants and Premature Ejaculation?
Let’s dive deep into the article to understand the relationship between antidepressants and PE.
Can you take antidepressants for Premature Ejaculation
Yes, you may take antidepressants such as Paroxetine and Sertraline for Premature Ejaculation.
Both Sertraline and Paroxetine are FDA-approved antidepressants used for treating psychological conditions. They belong to a class known as Selective Serotonin Reuptake Inhibitors (SSRI).
They increase the levels of the neurotransmitter Serotonin in the body, and PE can be caused due to low amount of Serotonin.
Some antidepressants cause delayed orgasms, which is why they are used in the treatment of Premature Ejaculation.
A study conducted on 43 men aged 22 to 63 showed Sertraline is quite effective for managing PE.
According to that study-
- The 20mg dosage of Sertraline increased the mean ejaculation interval to 7.6 minutes
- With 50mg of Sertraline, the mean ejaculation interval was increased to 13.1 minutes
- And the 100mg dosage increased the ejaculation interval to 16.4 minutes
Research reviewed how Sertraline was able to lengthen the time of ejaculation and was able to treat PE effectively and safely.
A study by the Asian Journal of Urology stated the daily use of Sertraline or taking it a few hours before sexual intercourse is effective in increasing ejaculation time.
According to a study conducted on nearly 100 men, Paroxetine, when taken both every day or a few hours before intercourse, increased ejaculation time.
Apart from Sertraline and Paroxetine, Dapoxetine is also used for treating Premature Ejaculation. Dapoxetine is an SSRI that is used only for treating Premature Ejaculation.

